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Proteostasis Therapeutics cms121
Cms121, supplied by Proteostasis Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cms121/cms121/pm37864765-183-9-15
Average 90 stars, based on 1 article reviews
cms121 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: CMS121 Partially Attenuates Disease Progression in Mouse Models of Huntington's Disease.
Article Snippet: Huntington’s disease (HD) is an autosomal dominant, predominantly adult-onset, progressive and eventually fatal neurodegenerative disorder for which there are still no disease-modifying treatments.. It is caused by an expansion of a trinucleotide repeat in exon 1 of the Huntingtin (Htt) gene (Httex1) that leads to the production of a mutant from of the Htt protein (mHtt) that contains an abnormally long polyglutamine tract.. The identification of the Htt protein and its disease-causing mutation has led to the development of a number of different cellular and animal models of HD.



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